Attraction
The positively-charged polymer is drawn to the negatively-charged microbe surface and binds to its membrane.
THE SCIENCE
Fast. Effective. Gentle.
A resistance-free, membrane-lytic technology invented at A*STAR — here’s how it works, why it keeps protecting, and how it stays gentle on skin, cells and the environment.
A*STAR LicensedMEMBRANE-LYTICRESISTANCE-FREE
Smart Ionic Shield™
Destroys harmful microbes in seconds — while staying gentle enough for daily skin.
A next-generation antimicrobial platform, exclusively licensed from A*STAR Singapore — forming a long-lasting protective layer while keeping skin nourished and healthy.
OriginA*STAR Singapore
FormatMacromolecular polymer
MechanismMembrane disruption
HOW IT WORKS
Three stages to safer skin.
A physical, membrane-lytic mechanism — not a chemical one that resistance can adapt to.
Disruption
It physically ruptures the membrane — a mechanical kill that microbes can’t readily evolve around.
Elimination
Microbes are neutralised on the surface, breaking the cycle of recurring infection — for up to 48 hours.
Performance
Fast, lasting, broad-spectrum.
One physical mechanism, three advantages you can rely on every day.
Fast-acting
Eliminates 99.9% of targeted germs within 30 seconds of contact.
Long-lasting
A stay-on layer keeps defending for up to 48 hours after one application.
Broad-spectrum
Active against Gram-positive and Gram-negative bacteria, fungi and viruses.
Evidence & numbers
The proof, tab by tab.
Speed, efficacy, comparison and safety data — the numbers behind the claims.
Validated safety tests
Independently assessed against international OECD & ISO standards.
Acute Skin Irritation
OECD 404
Acute Eye Irritation
OECD 405
Acute Skin Toxicity
OECD 402
Acute Oral Toxicity
OECD 425
Acute Inhalation Toxicity
OECD 436
Acute Systemic Toxicity
ISO 10993-11
Mutagenicity
OECD 471
Human Repeat Patch Test
HRIPT
Safe on cells
A multivalent positive charge makes it highly selective for microbes over healthy human cells.
Safe on skin & body
A macromolecule that does not penetrate skin — no systemic side effects or irritation.
Safe on environment
Amide-bonded and stable in storage, yet biodegradable by environmental enzymes.
Safety by design
Safe on skin, cells and the environment.
The same properties that make it effective are what make it gentle.
Skin safety
A large macromolecule that stays on the surface — no systemic exposure, gentle enough for fragile skin.
Cell safety
Highly selective toward microbial membranes, leaving healthy human cells untouched.
Environmental care
Stable in storage, yet biodegradable by environmental enzymes once its job is done.
Resistance science
Built to fight resistance, not fuel it.
Antimicrobial resistance occurs when microbes stop responding to treatment — making infections harder to cure and raising the risk of serious illness.
— World Health Organization
Chemical actives
Small-molecule antiseptics & antibiotics
Work by inhibiting biochemical pathways — repeated use lets microbes adapt, driving resistance over time.
Trisafe mechanism
Physical, membrane-lytic action
Ruptures the microbial membrane directly — a mechanical kill that’s hard to evolve around.
What makes Trisafe different
We turn antimicrobial science into everyday protection.
Every product is powered by the same breakthrough — the A*STAR-licensed Smart Ionic Shield™. It’s tough on bacteria, fungi and viruses, yet gentle on your skin, your cells and the environment. Here’s why it protects differently:
Fast Acting
Eliminates 99.9% of germs within 30 seconds.
Long Lasting
Continual protection for up to 48 hours after application.
Broad Spectrum
Effective against bacteria, fungi and viruses.
Anti-Drug Resistance
A unique membrane-lytic mechanism prevents the development of resistance.
Safe on Skin
A large macromolecule that does not penetrate skin — no systemic side effects or irritation.
Safe on Cells
Highly selective towards germs — not healthy human cells.
Safe on Environment
Stable under storage conditions, yet biodegradable by environmental enzymes.
Prevention, made possible
Protect skin before infection starts.
Clinically validated, resistance-free, and gentle enough for daily use.